AREG (amphiregulin (schwannoma-derived growth factor))

AREG ( amphiregulin ( schwannoma - derived growth factor ) )

Amphiregulin (areg) And Epidermal Growth Factor (egf): Disparate In Egfr Signaling And Trafficking

AMPHIREGULIN (AREG) AND EPIDERMAL GROWTH FACTOR(EGF): DISPARATE IN EGFR SIGNALING AND TRAFFICKING

Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity.

Schwannoma-derived growth factor (SDGF) is a mitogen and neurotrophic protein which belongs to the epidermal growth factor (EGF) family. There are two basic amino acid clusters in the SDGF molecule which are homologous to the nuclear targeting signal of the simian virus 40-encoded large tumor antigen. Mutational analysis of these clusters showed that they function as nuclear targeting signals, ...

Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells

Schwannoma-derived growth factor (SDGF) was initially isolated from schwannoma cells as a mitogen for glial cells and fibroblasts. The present data show that SDGF causes the morphological and molecular differentiation of rat PC12 cells in a manner similar to, but distinguishable from nerve growth factor (NGF). It also promotes PC12 survival in serum-free conditions. SDGF induced changes include...

Platelet-derived growth factor.

Platelet-derived growth factor was purified from fresh platelets by a large-scale procedure not involving the use of SDS (sodium dodecyl sulphate). The product, 0.5 mg of platelet-derived growth factor, obtained from about 3 x 1013 platelets migrated as a single component in analytical gel electrophoresis in the presence of SDS and showed no inhomogeneity on sedimentation-equilibrium analysis i...